|Recent review article regarding the interactions between chromatin modifiers|
and transcription factors in cardiovascular disease.
such as cardiomyocytes, endothelial cells, and vascular smooth muscle cells will behave abnormally (increased cell death, cell division, altered phenotype, etc) downstream of genetic mutations and/or environmental stimuli. Genetic mutations and/or environmental stimuli (for example, high fat diet, smoking, etc) alter the signaling in the cells leading to dysregulated expression of genes. We know that altered signaling promotes changes in transcription factor and chromatin modifier expression, activity and/or function leading to the dysregulated expression of genes in cardiovascular disease. Although scientists have identified several key transcription factors and chromatin modifiers that are important in cardiovascular disease development, the role of the interactions between them are less clear. However, by better understanding the interactions of transcription factors and chromatin modifiers in cardiovascular disease, we will hopefully be able to develop more and better therapeutics in the treatment of cardiovascular diseases. We've recently written a review published in Frontiers in Cardiovascular Medicine that describes some of these known interactions and highlights some of the questions that remain in the field. So check it out to learn more about transcription factor and chromatin modifier interactions in cardiovascular disease! I would love to hear what you think about this topic! Feel free to comment below or send me an email. Also, don't forget to follow me on Twitter!